Subsequently, we chose to further characterize the regulatory connection between TTF-1 and VEGF for these reasons: (i) Vegf expression perturbation occurs in Ttf-1 mutant mice 22 , 23 , (ii) VEGF was not established as a direct transcriptional target of TTF-1 , (iii) VEGF is a master regulator of angiogenesis 24 , and (iv) Our focused angiogenesis factor expression profiling detected an overall trend of angiogenic factor upregulation by TTF-1 ( Fig. 1B ), suggesting a proangiogenic phenotype associated with the TTF-1-on state.
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Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome.
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