Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.

Acta Neuropathol Commun · 2016 · PMC4766625 · PMID 26916334

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highly significantno p-value reported

By contrast, at more advanced age (20 mo) spine counts of cognitively impaired hTau40 AT mice demonstrated a highly significant decrease (reduction in CA1: −35 % and CA3: −25 %) compared to age-matched WT mice (Fig. 9c - d ).

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