Experimental vitamin B12 deficiency in a human subject: a longitudinal investigation of the performance of the holotranscobalamin (HoloTC, Active-B12) immunoassay.

Total serum vitamin B 12 versus holotranscobalamin (HoloTC) There was a very highly significant positive correlation, with r = 0.70), between total serum vitamin B 12 and HoloTC concentrations (Fig. 1 b; Table 1 ).

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