An oxygen-insensitive Hif-3α isoform inhibits Wnt signaling by destabilizing the nuclear β-catenin complex.

Hif-3α2 is a nuclear protein with HRE-dependent transcriptional activity Co-expression of Hif-3α2 with p2.1, a HRE reporter construct ( Semenza et al., 1996 ), resulted in a highly significant, 11.3-fold increase in the reporter activity in HEK293 cells ( Figure 2A ).

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