Influence of Equatorial CH⋅⋅⋅O Interactions on Secondary Kinetic Isotope Effects for Methyl Transfer.

6 , 7 Nonetheless, an apparent trend in recent experimental T 3 KIEs for wild‐type and mutant COMTs has been interpreted as new evidence for compression. 2 , 3 Meanwhile, the functional importance of unconventional CH⋅⋅⋅O hydrogen bonding in AdoMet‐dependent methyltransferases has been noted from a survey of high‐resolution crystal structures, 2 but the possible influence of these interactions on KIEs for methyl transfer is unknown.

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