Barely Significant
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Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity.

PLoS One · 2016 · PMC4771163 · PMID 26928328

Europe PMCDOI
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hedged sentence
0.0010
closest p · 0.0× alpha
0.0010
boldest claim

The sentences

highly significantp<0.001actually significant
Results VTX-2337 induces NLRP3 inflammasome activation and production of IL-1β and IL-18 by THP-1 cells and PBMC Treatment of THP-1 cells with VTX-2337 induced a highly significant (p<0.001, unpaired t test), concentration-dependent increase in IL-1β and IL-18 mRNA, consistent with TLR-mediated activation of NF-ĸB ( Fig 2A and 2B ).

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