Determinants of ventilation and pulmonary artery pressure during early acclimatization to hypoxia in humans.

An example at the molecular level is that there may be significant variation between individuals in the responsiveness of the hypoxia‐inducible factor (HIF) transcription activation system (Brooks et al . 2009 ).

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For example, genetic variants within the HIF system (PHD2, HIF2α) have already been identified as functionally highly significant for haemoglobin concentration in the Tibetan population (Beall et al . 2010 ; Simonson et al . 2010 ; Yi et al . 2010 ).

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