Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice.

Gene expression analysis of epithelial integrity markers including ZO-1, Occludin-1 and E-cadherin also yielded no significant differences across the treatment groups relative to vehicle treated mice, although there was a small trend towards a reduction in ZO-1 and Occludin-1 in co-infected mice ( Fig. 8F–H ).

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