highly significantP < 0.001
As shown in Figs 4 C,D and 5 out of 18 hits, represented by dexamethasone, flumethazone, colchicine, thimerosal, and doxorubicin displayed highly significant effect (P < 0.001) at 1 μM; 4 out of them, i.e. colistimetate, megestrol, melphalan, and metronidazole showed a significant effect (P < 0.05) at 1 μM; while cyproterone and nitrofurantoin compounds displayed a slight dose-response trend at the doses used, accounting for a total of 11 compounds (61%) globally validating approximately 0.5% of hits from the primary screening.