Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo.

Interestingly, the LPS-group revealed a highly significant mRNA increase in the myenteric plexus of duodenal samples by 17.2±5.2-fold ( Fig 2B , p < 0.01), of ileal Gfap level by 3.5±0.8-fold (p < 0.01, Fig 2C ) and of colonic samples by 15.0±3.1-fold ( Fig 2D , p < 0.01).

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Similar to the glial Sox10 protein analysis we merely observed a statistical trend for decreased neuronal cell number in the small intestine by 30% at most ( S1B Fig ).

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