Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications.

Since even small changes in mRNA expression might be significant at the early stage of the disease, but might differently be identified by two fundamentally different analysis methods, such as RNA-seq and microarray, we decided to combine the results from both analyses giving at total of 114 de-regulated genes in SN ( S3 Table ), thereby accepting potentially lower stringency standards.

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