LARVA: an integrative framework for large-scale analysis of recurrent variants in noncoding annotations.

The P -value for 16 mutations in the bottom replication timing 1 kb region from the empirical distribution shows only marginal significance (3.994 × 10 −4 ), but the binomial distribution could inflate it to 2.585 × 10 −13 due to its bad fitting of the heavy tails on the right side.

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