Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.

However, consistent with the changes observed by phase contrast microscopy (Fig 1C ), we found a highly significant reduction in cell diameter of cells at CPD 73 from a mean of 27.7 μm (DMSO control) to 24.7 μm on AZD8055 treatment (unpaired t-test, p<0.02, Table 1 ), a cell diameter highly similar to that of low CPD untreated cells.

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