extremely significantp < 0.0001
Significance values are denoted by asterisks as defined by GraphPad Prism version 6.04: ****extremely significant (p < 0.0001); ***extremely significant (0.001 ≤ p ≤ 0.0001); **very significant (0.01 ≤ p ≤ 0.001); *significant (0.05 ≤ p ≤ 0.01).