The relationship between apolipoprotein E gene ε2/ε3/ε4 polymorphism and breast cancer risk: a systematic review and meta-analysis.

Onco Targets Ther · 2016 · PMC4789883 · PMID 27022282

Europe PMC DOI

hedged sentences

0.0650

closest p · 1.3× alpha

0.0650

boldest claim

The sentences

marginal significanceP =0.065so close (0.05 < p ≤ 0.1)

Grouping studies by study design and source of controls revealed only marginal significance for the comparison of alleles ε4 with ε3 in hospital-based studies (OR =1.33, 95% CI =0.98–1.79, P =0.065, I 2 =30.2%).

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marginally significantP =0.065so close (0.05 < p ≤ 0.1)

Subgroup analyses revealed that the comparison of allele ε4 with ε3 was significant in Asians (OR =1.58, 95% CI =1.17–6.32, P =0.003, I 2 =12.1%) and in studies that used the restriction fragment length polymorphism (RFLP) genotyping method (OR =1.27; 95% CI =1.01–1.61, P =0.045, I 2 =34.3%), and was marginally significant in hospital-based studies (OR =1.33; 95% CI =0.98–1.79, P =0.065, I 2 =30.2%), without heterogeneity.

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