Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials.

J Immunother Cancer · 2016 · PMC4791805 · PMID 26981245

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highly significantno p-value reported

In 2006, Galon and colleagues, using digital imaging and image quantification software [ 2 ], reported a strong and highly significant correlation in colon cancer between increased survival and the presence of immune cell densities (CD3 + , CD8 + , Granzyme B + , CD45RO + cells) at the invasive margin and center of the tumor.

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