Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.

The greater inhibitory potency of m 7 Gp S pppp S m 7 G (D3 diastereomer) (12b) compared to m 7 GDP (1) or m 2 7,3′- O GpppG (16) is highly significant ( Fig. 2 B; P -values 0.003 and <0.001, respectively).

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