Early administration of low dose norepinephrine for the prevention of organ dysfunctions in patients with sepsis

Methods To achieve and maintain MAP at ≥ 70 mm Hg and central venous oxygen saturation ≥ 70%, in Group Early-NE (n = 16), fluid challenge and norepinephrine therapy concurrently was started within 6 hours at a dose of 0.1 μg/kg/min to a maximal dose of 0.3 μg/kg/min in sepsis patients with a decreasing trend in MAP from the baseline.

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