Dual antiplatelet therapy and newer agents: More efficacy but lets keep the brain safe!!

In a systematic review of RCT's with mono versus dual antiplatelets among stroke patients, the authors concluded a improved stroke recurrence with the use of dual antiplatelets at the expense of a nonsignificant trend for major bleeding complications, although the overall events were small in number with wide confidence intervals (CIs). 12 The recent CHANCE trial, 13 conducted among patients with “minor stroke” and TIA, compared efficacy of aspirin and clopidogrel given for first 21 days versus aspirin alone in reducing recurrence of stroke at 90 days.

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