Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals.

This may be significant as the transformation of the American diet over the last 30 years has been one of increased carbohydrate content, particularly the refined grains and simple sugars found in processed foods. 26 , 32 As increased fructose intake has been implicated in the explosion in diabetes rates, 33 , 34 understanding how EDCs interact with secular trends in dietary carbohydrate content and composition will be important for contextualizing the importance of EDCs in the current metabolic disease epidemic.

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