Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei.

While vector control in conjunction with extensive surveillance can have highly significant local impact on the disease burden, there is no realistic prospect of a vaccine ( La Greca and Magez, 2011 ) and chemotherapy is practically the only option in most areas ( Delespaux and de Koning, 2007 , Jannin and Cattand, 2004 ).

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