Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.

PLoS Genet · 2016 · PMC4806848 · PMID 27010727

Europe PMC DOI

hedged sentence

0.0644

closest p · 1.3× alpha

0.0644

boldest claim

The sentences

marginal significancep = 0.0644so close (0.05 < p ≤ 0.1)

Only haplotype A - G - C of rs12461727, rs73038469, and rs4803406 in LD block B2 in CYP2A7P1 and CYP2B7P1 showed a dose-response pattern and had a p value near a marginal significance level (raw p = 0.0644).

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