First-Generation Antipsychotic Haloperidol Alters the Functionality of the Late Endosomal/Lysosomal Compartment in Vitro.

Treatment with haloperidol increased the lysosomal pH in a dose-dependent manner, an effect that was highly significant ( p < 0.0001) with doses of 10 (6.56 ± 0.24, mean ± SEM, n = 15) and 25 μM (8.18 ± 1.46), but not with 5 μM (4.21 ± 0.41) ( Figure 2 ).

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