highly significantP < 0.0005
The mean digital value of the percentage of positivity of 5mC immunohistochemical expression (5mC%) was lower in colorectal carcinoma in comparison to colorectal adenomas and control group with mean differences of (−0.27567 ± 0.03) and (−0.32567 ± 0.03), respectively; and both differences are highly significant ( P < 0.0005), whereas 5mC% was nonsignificantly lower in colorectal adenomas in comparison to control group ( P = 0.099) with a mean difference of (−0.05 ± 0.03) as shown in Table 4 .