Heterogeneity in global gene expression profiles between biopsy specimens taken peri-surgically from primary ER-positive breast carcinomas.

There was a significant tendency to an increase in study I (expression levels higher in time point B than A) and a decrease in study II (expression levels lower in time point S than D) that resulted in a marginally significant ( p = 0.024) heterogeneity between the studies.

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For example, we have previously described the highly significant impact of specimen type (core-cut vs excision) on pAKT and pERK1/2 staining [ 2 ].

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