Interestingly, minicircle-mediated eNOS (MC-eNOS) gene transfer showed a highly significant increase in CD31 mRNA expression by 1.8-fold compared to P-eNOS, P-GFP, MC-GFP, and un-transfected control (Fig. 8 ).
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Minicircle DNA-mediated endothelial nitric oxide synthase gene transfer enhances angiogenic responses of bone marrow-derived mesenchymal stem cells.
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