Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows' milk.

When we pooled data from both sequences, the magnitude of the increase in gastrointestinal symptom scores following the consumption of milk containing both β-casein types tended to be greater in lactose intolerant subjects than in lactose tolerant subjects, and this was of borderline significance (least squares mean difference: 1.087; 95 % CI −0.0652, 2.2392; P = 0.0638).

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Finally, using the SCIT, we found that consumption of the milk containing both β-casein types was associated with small but highly significant increases in response time and error.

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