A borderline significant inverse trend was detected between increasing quartiles of cumulative serum PFOA and risk of currently treated asthma in unlagged analyses (OR for top versus bottom quartile = 0.53, 95% CI = 0.16, 1.69, P trend = 0.27 for continuous log PFOA, P trend = 0.05 for categorical PFOA), and no significant association was detected in analyses with a 10-year lag (OR for top versus bottom quartile = 0.52, 95% CI = 0.09, 2.84, P trend = 0.53 for continuous log PFOA, P trend = 0.17 for categorical PFOA).
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A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans.
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Some evidence of a positive trend was observed between estimated cumulative serum PFOA and risk of rheumatoid arthritis with no lag (23 cases; OR for highest versus lowest quartile = 4.45, 95% CI = 0.99, 19.9, P trend for continuous log PFOA = 0.54, P trend for categorical PFOA = 0.04), although the association was attenuated with a 10-year lag (OR = 2.62, 95% CI = 0.47, 14.7, P trend for continuous log PFOA = 0.75, P trend for categorical PFOA = 0.06).
The Norwegian cohort study reported a marginally significant positive association between a 1-ng/mL increase in maternal perinatal plasma PFOA concentration and parent-reported number of episodes of gastroenteritis in the third year (coefficient = 0.31, 95% CI = 0.002, 0.61), but no significant association with number of gastroenteritis episodes in the first three years or the presence versus absence of gastroenteritis in years 1–3 or 3 (Granum et al. 2013 ).