Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis.

Interestingly, although GMMA from both STm G Δ msbB Δ pagP and SEn G Δ msbB Δ pagP contained only penta-acylated lipid A, they showed an approximately 3-fold difference in their potentials to elicit IL-6 release from human PBMC (3.15 ng/ml versus 0.89 ng/ml), which was highly significant ( P < 0.0001).

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