Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB.

We found that 4-DACL decreased the basal NF-κB activity in a concentration dependent manner and also reduced NF-κB activation in a highly significant manner when stimulated with TNFα, LPS or FCS for 8 h (Figure 4 A-C).

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