Age and gender were included into the model in order to adjust for potentially confounding variables, since there were significant age differences between the control and AD group and a statistical trend was found towards higher proportion of male in the control group (see Human brain samples and neuropathological examination in the “ Methods ” section).
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TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus.
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