The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.

J Exp Med · 2016 · PMC4821649 · PMID 27001747

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highly significantno p-value reported

4 D ) a highly significant association between genes showing reduced expression in both Irf1 −/− and Irf8 m/m mutants (group a) and the cluster 1 binding scheme (cobinding IRF8/IRF1/STAT1/PU.1) and to a lesser degree to clusters 3 and 5, which recruit IRF8 or IRF1 uniquely in conjunction with STAT1 and PU.1 ( Fig. 4 D ).

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