Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.

To prevent that bridges among circuits might be masked by the occurrence of marginally significant correlations (concordant but not identified in both dataset based on the defined correlation thresholds), the results from the two MAGIA 2 analyses were merged and the nodes sharing relationships in both datasets were selected: as shown in Figure 2A , a new “child” network have been finally derived that included such eight nodes along with their first neighbors (for a total of 13 miRNAs and 60 genes) in the mixed circuits network.

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