In addition, GATA3 significantly repressed ‘stem cell' genes whose downregulation is essential for further T cell development ( LMO2 , MEF2C and SPI1 ) 33 34 , and/or that are involved in the development of other haematopoietic lineages such as CD79A for B cell development (downregulation of EBF1 , expressed at low levels, was observed but just failed to reach significance, P =0.052) and ID2 for NK-lineage differentiation 35 ( Fig. 5e , Supplementary Data 1 ).
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GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate.
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