Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer.

At 24 h, all four cell lines showed NIS expression and iodide uptake at MOI 1, with a highly significant difference (two-way ANOVA P <0.001) compared with cells treated with the competitive inhibitor of iodide uptake (potassium perchlorate) ( Figure 2c ).

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