Associations between FAS rs2234767 and FASL rs763110 polymorphisms and the risk of lung cancer: a meta-analysis of 39,736 subjects.

29 – 31 Given the important role of FAS/FASL system in lung cancer, it is biologically plausible to propose that several polymorphisms in FAS/FASL genes may be significant in the genetic susceptibility to lung cancer on account of the fact that these polymorphisms possess the potential to alter the expression of FAS and/or FASL. 6 For instance, the FAS rs2234767 polymorphism was found to be capable of disrupting Sp1 transcription factor binding sites, thus diminishin

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Nevertheless, most results of the sensitivity analysis suggested at least a borderline significance of this association.

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