highly significantp < 0.001
We included seven HIV-1 integration site data sets for this analysis: two derived from this study (data sets of the same cell type combined; n = 1,484) and one other MDM data set (n = 754) and four other CD4 + T cell data sets (n = 4,613) obtained elsewhere 14 , 18 , 31 , 32 , 33 ( Table 2 ), By comparing the frequencies of HIV-1-hosting genes linked to clonal expansion of latently HIV-1-infected CD4 + T cells in gene hotspots and genes with single HIV-1 integration events, we observed a highly significant increase of genes linked to clonal expansion of latently HIV-1-infected CD4 + T cells in gene hotspots in CD4 + T cells (2.5×, p < 0.001), but not in MDMs ( Fig. 5b ), showing again that the repertoires of genes accessible to HIV-1 for integration in the two cell types were distinct.