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Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line.

PLoS One · 2016 · PMC4829234 · PMID 27070314

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a decreasing trendno p-value reported
Their activities peaked at 18 hours for caspase 9 and 24 hours for caspase 3/7 and 8, which was followed by a decreasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.