Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

The difference between these two groups was highly significant and demonstrates the importance of assaying functional marks in both normal and tumour tissues.

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To account for the correlation among marks we grouped the 82 marginally significant annotations into 15 biologically relevant, non-overlapping groups organized by mark and cell line, and partitioned across all groups in a joint model (see Methods, Table 1 , Fig. 5 and Supplementary Table 6 ).

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