Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog.

J Mol Cell Cardiol · 2016 · PMC4831045 · PMID 26853943

Europe PMC DOI

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closest p

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may not be significantno p-value reported

Finally, it is also possible that the 3-fold decrease in switch-cTnI affinity in the micromolar range (~ 25 to 75 μM) may not be significant in the context of the high apparent concentration of switch-cTnI in the thin filament. cNTnC and switch-cTnI are spatially confined in the thin filament such that the apparent concentration of switch-cTnI is high.

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