When we compared patients with high versus low JMJD6 expression, we observed a highly significant effect in samples with high Myc rather than low Myc expression (compare p values for left and right panels in Fig. 10a, c ).
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The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis.
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