Antihyperlipidemic effects of Citrus sinensis, Citrus paradisi, and their combinations.

Naringin may result in significantly higher levels of cholesterol metabolites, levels of cholesterol, and bile acids, which are not absorbed in the small intestine.[ 56 ] In general, endothelial dysfunction stage in coronary disease is related with total serum cholesterol levels,[ 57 ] moreover, HDL efficacy to reverse cholesterol transport might be significant for the function of endothelium as indicated in hypercholesterolemic patient that HDL plays a defensive role in endothelial function.[ 58 ] A possible mechanism for lipid lowering effect of citrus flavonoids might be due to its antioxidant effects and due to its inhibition of uptake of oxidized LDL by macrophages, reduced LDL aggregation, and reduced oxidation of LDL cholesterol,[ 59 ] since macrophages play an important role in the early diagnosis.

also in 2,435 other papers