highly significantp<0.001
Interestingly, a highly significant increase of SIRT4 transcripts was detected in human skin biopsies obtained from photoaged skin (fold increase: 1.91 ± 1.23; median ± SEM, p<0.001; n=16) compared with non-photoaged skin of the same individuals aged 60-66 years or to skin of young individuals (n=15; age range 18-25 years) (Fig. 5A ).