A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers.

Deletions (including frameshift deletions; hGIS1, P =0.0004; hGIS2, P =0.0038), mononucleotide repeat frameshifts (hGIS1, P <0.0001; hGIS2, P <0.0001) and splice-site mutations (hGIS1, P =0.0003; hGIS2, P =0.0002) were present at significantly increased levels in both hGIS1 and hGIS2 genes, and nonsense mutations were present at statistically significant increased levels in hGIS1 and at borderline significant levels in hGIS2 (hGIS1, P =0.01; hGIS2, P =0.0613) ( Supplementary Data 3 ).

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