In the deep parietal white matter in an elderly cohort that included AD, VaD and cognitively normal cases, MAG:PLP1 showed a highly significant negative correlation with severity of SVD and a highly significant positive correlations with the concentration of the vasoconstrictor endothelin-1 (EDN1) and with the concentration of vascular endothelial growth factor (VEGF) [ 11 , 12 ].
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