High-throughput sequencing of partially edited trypanosome mRNAs reveals barriers to editing progression and evidence for alternative editing.

For each replicate, >80% of all IPSs were common with at least one other replicate, and when the significance of the overlap was tested in a pairwise manner using the hypergeometric distribution, the P -value for all pairs in both transcripts was highly significant (RPS12: 2.89 ×10 −22 for replicate 1 vs. replicate 2 [R1:R2], 5.73 ×10 −15 for R2:R3, 3.83 ×10 −14 for R1:R3; ND7-5′: 3.41 ×10 −6 for R1:R2, 3.70 ×10 −10 for R2:R3, 3.80 ×10 −8 for R1:R3).

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