These epidemiological studies mentioned above suggested a decreasing trend of incident ESRD over time; however, the methods of data collection, result expression and follow-up rates varied enormously among the studies.
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Improved incidence of end-stage renal disease of type 1 diabetes in Japan, from a hospital-based survey.
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The sentences
The time-dependent variables of HbA1c and systolic BP were both significantly associated with onset of ESRD, and the effect of year of T1DM diagnosis, as a categorical variable, was cancelled out (model C1), while the year of T1DM diagnosis, as a continuous variable, showed borderline significance (model C2).