In contrast, two of the random SNPs that had highly significant correlations ( P < 0.01) were in genes previously linked to malaria resistance, namely, CDH13 , encoding cadherin 13 , and HS3ST3B1 , encoding heparan sulfate 3-O-sulfotransferase 3B1.
S4 A , Supplementary Material online). When a test for general population differentiation, that is, irrespective of malaria, was applied using the X T X statistic described by Gunther and Coop (2013) , significant ( P < 0.05) signals were found for SNPs rs1128127 in the DERL3 gene and rs84833095 in the TLR1 gene, and marginally significant signals ( P < 0.10) were found for SNPs rs2706384 in the IRF1 gene and rs1803632 in the GBP7 gene ( supplementary fig.