Barely Significant
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The SafeBoosC II randomized trial: treatment guided by near-infrared spectroscopy reduces cerebral hypoxia without changing early biomarkers of brain injury.

Pediatr Res · 2016 · PMC4840238 · PMID 26679155

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highly significantno p-value reported
This could be because the burden of cerebral hypoxia—even though the reduction in the experimental group was highly significant—was insufficient for the release of the intracellular S100β into the systemic circulation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.