Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis.

Simple effects tests to investigate group differences at each time point showed a trend where the highly significant group difference at time zero (described above) became not quite significant after two weeks and then not significant after four weeks (F = 233.5, P < 0.0001; F = 3.29, P = 0.072; F = 0.28, P = 0.60, respectively, with df = 1, 114 for all three tests).

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